Best Supplements for IVF: Which Nutrients and Doses Have Actually Been Studied?

If you’re preparing for IVF, you’ve probably come across enormous lists of recommended supplements. But one of the most important things to look at isn’t simply which ingredients a fertility supplement contains — it’s how much it actually provides.

Research into fertility and IVF has studied specific nutrients at specific doses. Here are three of the most researched nutrients to know about when preparing for IVF.

1. CoQ10 for IVF

Coenzyme Q10 (CoQ10) is one of the most extensively researched supplements in assisted reproduction.

A 2024 systematic review and meta-analysis examined six randomised controlled trials involving 1,529 women with diminished ovarian reserve undergoing IVF/ICSI. Overall, CoQ10 pretreatment was associated with improvements in several outcomes, including the number of oocytes retrieved and clinical pregnancy rate — although the researchers emphasised that larger, higher-quality trials are still needed.

Importantly, fertility research has often investigated CoQ10 at doses far higher than the small amounts found in many standard multivitamins.

That’s why checking the actual milligrams of CoQ10 per daily serving matters — not just whether “CoQ10” appears on the label.

CORE3 provides 450 mg of CoQ10 in a single daily capsule.

2. Vitamin D Before IVF

Vitamin D is another nutrient frequently studied in fertility.

A large 2026 randomised controlled trial involving 876 women with PCOS undergoing IVF specifically studied 4,000 IU of vitamin D per day for up to 90 days before IVF.

The supplementation substantially increased participants’ vitamin D levels. CORE3 provides the same 4,000 IU daily dose of vitamin D3 used in this recent IVF trial.

The standard UK recommendation during pregnancy is considerably lower at 400 IU (10 µg) daily, and the NHS advises not exceeding 4,000 IU (100 µg) of vitamin D per day unless advised otherwise.

3. Folate Before IVF and Pregnancy

Folate is particularly important because supplementation should begin before conception, rather than waiting for a positive pregnancy test.

NICE recommends 400 µg of folic acid daily for people planning a pregnancy and during the first 12 weeks, with 5 mg prescribed in certain higher-risk circumstances.

Some fertility supplements instead contain methylfolate (5-MTHF), a bioactive form of folate.

CORE3 contains 1,000 µg of methylfolate (5-MTHF) per capsule.

If your doctor or fertility clinic has specifically prescribed 5 mg folic acid, CORE3 should not be used as a substitute for that prescription.

So, What Is the Best Supplement for IVF?

There isn’t a supplement that can guarantee IVF success, and supplements should never replace the individual advice given by your fertility clinic.

But when comparing fertility supplements, look beyond a long ingredients list.

Consider:

• Are the ingredients relevant to preconception?
• Are the actual doses clearly stated?
• Have those nutrients been studied in fertility or IVF research?
• How many capsules do you need to take every day?

This is exactly why we created Ovare CORE3.

Why Choose CORE3 When Preparing for IVF?

CORE3 combines three targeted preconception nutrients in one capsule per day:

450 mg CoQ10
4,000 IU Vitamin D3
1,000 µg bioactive methylfolate (5-MTHF)

Rather than trying to fit dozens of ingredients into a fertility multivitamin, CORE3 focuses on three carefully selected nutrients at substantial doses, including doses comparable to those investigated in fertility research.

It is also:

✓ One capsule per day
✓ Doctor-created
✓ Vegan
✓ Halal
✓ Made in the UK

If you’re preparing for IVF and want a simple, high-dose approach to preconception supplementation, discover Ovare CORE3 today.

References

Hu, K-L. et al. (2026) ‘Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial’, BMJ, 392, e087438. doi: 10.1136/bmj-2025-087438.

Lin, G., Li, X., Yie, S.L.J. and Xu, L. (2024) ‘Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis’, Annals of Medicine, 56(1), 2389469. doi: 10.1080/07853890.2024.2389469.